NAD+ VITAL ENERGY COMPLEX
AM Ritual · Skin Longevity Protocol™ — Step 04 · Taken with breakfast
There’s a kind of tiredness that isn’t fixed by sleep. A recovery that takes longer than it used to. A sense that your body is working harder to produce the same results.
This is what a 50% drop in NAD+ between 40 and 60 feels like from the inside.
Two capsules, every morning. The inside layer that your topicals can’t replace.
- Cellular energy that supports how you feel all day* NAD+ fuels the mitochondrial pathways that power every cell in your body. When levels are restored, the difference isn’t dramatic — it’s the quiet, consistent feeling of your body keeping up.
- Your topicals work harder because your cells do* PDRN activates fibroblast repair. Retinol drives cell turnover. But both processes depend on cellular energy. NAD+ is the fuel that makes the topical half of your protocol compound.
- Protection from the inside — Quercetin & Resveratrol* Quercetin helps maintain the NAD+ you supplement. Resveratrol supports the same cellular longevity pathways. Together they create a 3-in-1 stack designed to reinforce each other.
- A morning ritual that compounds* Two capsules with breakfast. No complexity, no timing windows, no stack management. Consistent supplementation is what makes this step effective — simplicity is by design.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
“No topical serum can compensate for a cellular energy deficit. This is the layer that makes everything else work harder — from the inside.”
Physician’s Clinical Rationale
The inclusion of NAD+ supplementation in this protocol reflects a clinical reality I observed consistently: the topical results patients expected were limited by what was happening at the cellular level. NAD+ decline after 35 is well-documented — its consequences for skin biology are direct. Reduced sirtuin activity means less collagen gene expression. Reduced mitochondrial efficiency means slower overnight repair. The 500mg dose was selected based on pharmacokinetic data showing meaningful NAD+ repletion. Quercetin and Resveratrol were added specifically to protect and amplify the NAD+ mechanism — not as generic antioxidants.
— Dr. Gilbert Maleke, MD · Founder, VitaalSkin
500mg
NAD+ per serving — clinically meaningful repletion dose
~50%
NAD+ decline between ages 40–60 without supplementation
3-in-1
NAD+ · Quercetin · Resveratrol — synergistic stack
The Layer No Topical Can Replace
Skincare works at the surface. But the biological processes that determine how your skin ages — collagen gene expression, DNA repair, barrier regeneration — happen at the cellular level, powered by cellular energy.
NAD+ is the coenzyme at the center of that energy system. It declines approximately 50% between the ages of 40 and 60. No serum replaces what that decline takes away.
Step 04 is the inside component that completes the protocol — making the topical steps work the way the biology says they should.
Outside-in meets inside-out. This is where they connect.
The Cellular Energy Bridge
PDRN activates fibroblasts. Retinol drives cell turnover. Both require cellular energy to function. NAD+ is the fuel that makes the topical half of the protocol compound.
A Synergistic 3-in-1 Stack
NAD+ 500mg restores the coenzyme. Quercetin 250mg slows its degradation. Resveratrol 150mg activates the longevity enzymes (Sirtuins) that NAD+ powers.
The Simplest Step in the Protocol
Two capsules with breakfast, every morning. No timing windows, no stack management. Just the consistency that makes supplementation work.
What This Supplement Supports*
Supports Cellular Energy*
NAD+ fuels the mitochondrial pathways that power fibroblast activity, DNA repair, and barrier regeneration — the biological processes underlying skin longevity.
Activates Longevity Enzymes (Sirtuins)*
NAD+ is the essential cofactor for sirtuin activation — the enzymes that regulate collagen gene expression, cellular stress resistance, and inflammatory control.
Protects NAD+ from Degradation (Quercetin)*
Quercetin inhibits CD38 — the primary enzyme that degrades NAD+. More of what you supplement is retained and available to cellular repair mechanisms.
Amplifies the Topical Protocol (Resveratrol)*
Resveratrol activates SIRT1 and supports reduction of systemic inflammatory burden — the invisible process that suppresses the results of every topical active in the protocol.
Supports Cognitive Clarity & Daily Vitality*
NAD+ supports mitochondrial function throughout the body — the same cellular energy pathways that affect mental performance, focus, and how you feel day to day.
Supports Overnight DNA Repair*
Peak cellular repair happens at night. NAD+ fuels the PARP enzymes responsible for DNA damage repair — the same process that slows measurably after 35.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
In use
Video coming soon
Two Capsules.
Every Morning. With Breakfast.
Take 2 capsules with breakfast
Take with 6 oz (177mL) of water and food. Taking with food improves tolerability and supports absorption. Morning timing aligns supplementation with the body’s peak cellular activity window.
Pair with your AM topical ritual
Apply PDRN Serum and HydraBarrier first, then take your capsules with breakfast. The topical and internal protocols are designed to work together in the same morning window.
Consistency is the protocol
The cellular energy benefits of NAD+ supplementation are cumulative — they build over weeks and months of daily use. Missing occasional days has minimal impact; missing months does not.
Synergistic Pairing
Take NAD+ alongside KSM-66 (Step 05) for the complete inside-out protocol — cellular energy + cortisol management address the two primary internal drivers of skin aging simultaneously.
Science, Dosing & Ingredients
A 3-in-1 cellular longevity stack. Each ingredient was selected for a specific role in the NAD+ pathway — not as a generic antioxidant blend.
NAD+ (Nicotinamide Adenine Dinucleotide)
500 mg per serving
Essential coenzyme for mitochondrial energy production, sirtuin activation, DNA repair via PARP enzymes, and collagen gene expression
Quercetin Dihydrate
250 mg · Sophora japonica
CD38 inhibitor — slows NAD+ degradation, increasing the cellular availability of supplemented NAD+
Resveratrol (98%)
150 mg · Japanese Knotweed root
SIRT1 activator; supports reduction of systemic inflammatory signaling that suppresses collagen synthesis and skin repair
Veggie Capsule (HPMC)
Delivery system
Plant-derived, vegan, no animal-derived gelatin — clean delivery format consistent with the protocol’s formulation standards
Morning Protocol
- 1 PDRN Serum (topical)
- 2 HydraBarrier HA Cream
- 3 NAD+ (2 capsules with food)
- 4 KSM-66 (1 capsule, optional AM)
- SPF SPF 30+ (your favorite)
Dosing Guidelines
- 2 capsules per day
- 6oz water minimum
- AM Take with food
- 30d 60 capsules = 30-day supply
- NAD+ (Nicotinamide Adenine Dinucleotide)500 mg per servingCoenzyme essential for mitochondrial energy production, sirtuin activation, DNA repair
- Quercetin Dihydrate Extract250 mg · Sophora japonica, whole flower budCD38 inhibitor; maintains NAD+ levels by slowing enzymatic degradation
- Japanese Knotweed Extract (98% Resveratrol)150 mg · Polygonum cuspidatum, rootHigh-purity SIRT1 activator; supports reduction of systemic inflammatory signaling
- Other ingredients — HPMC (vegetable capsule), Microcrystalline Cellulose, Brown Rice Flour, Olive Oil, Silicon Dioxide, Magnesium Stearate
Do not exceed recommended dose. Pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before use. Keep out of reach of children. Store in a cool, dry place.
Is This Supplement Right for You?
Your Questions, Answered
No. NAD+ is a cellular coenzyme, not a stimulant. It supports the mitochondrial pathways that produce cellular energy — the effect is not a caffeine-like burst, but a gradual, consistent sense of your body’s repair and recovery systems functioning more efficiently over weeks of daily use.
NAD+ supplementation is cumulative — plasma NAD+ levels begin to rise within the first 1–2 weeks, with meaningful cellular impact building over 4–8 weeks of consistent daily use. The benefits are not dramatic or immediate; they are the quiet, compounding effect of cellular systems operating more efficiently.
Generally compatible with most supplements. However, if you are taking prescription medications — particularly blood thinners, chemotherapy agents, or immunosuppressants — consult your physician before use. The resveratrol component can interact with certain medications.
NAD+ addresses cellular energy depletion — one of the two primary internal drivers of accelerated skin aging. KSM-66 addresses cortisol elevation — the other. Together, they form the complete inside layer of the protocol: energy restored, stress biology managed.
The clinical literature on NAD+ supplementation supports daily use at doses of 250–500mg as well-tolerated in healthy adults. As with all supplementation, we recommend periodic review with your physician, particularly if your health status changes.
We offer a 30-day satisfaction guarantee. If you are not happy with your results, contact us for a full refund — no questions asked.
This Supplement Is Just Step 04.
The Inside Layer.

Step 01
PDRN Serum

Step 02
HydraBarrier Cream

Step 03
Retinol + Peptides

Step 04
NAD+ Capsules

Step 05
KSM-66 Capsules
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