STRESS BALANCE ADAPTOGEN BLEND
PM Ritual · Skin Longevity Protocol™ — Step 05 · Taken before sleep
There’s a kind of aging that doesn’t come from time — it comes from stress. The cortisol that never fully switches off. The skin that reacts to everything. The sleep that never quite delivers on its promise.
This is the driver most skincare completely ignores.
Step 05 is the evening ritual that lowers the biological noise — so the repair your skin is trying to do overnight can actually happen.
- Skin that stops reacting to everything* Chronic cortisol degrades the skin barrier and keeps inflammation elevated. When cortisol comes down, skin becomes less reactive, less sensitive, and more capable of holding onto what you put on it.
- Sleep that actually repairs* The skin’s peak mitotic window — when cellular division is highest — is 11pm–4am. Deep, uninterrupted sleep is when it happens. KSM-66 supports the sleep architecture that unlocks that window.
- Your serums working in a calmer environment* Lower cortisol at night means the PDRN, retinol, and HA Cream you applied earlier work in a less inflamed, more biologically receptive environment. Less resistance, more result.
- The protocol that finally makes stress management feel like skincare* Two capsules before sleep. No sedation, no grogginess. Just the quiet biological shift that comes from an adaptogen with 22+ clinical studies behind it.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
“Managing the stress response is not a wellness luxury. It is the skin longevity strategy that makes everything else possible.”
Physician’s Clinical Rationale
In 30 years of preventive medicine, chronic cortisol elevation was one of the most consistent — and most ignored — drivers of accelerated aging I observed. Its effects on skin biology are direct and measurable: cortisol suppresses fibroblast collagen synthesis, degrades tight junction proteins in the barrier, and maintains the pro-inflammatory cytokine environment that accelerates cellular aging. KSM-66 was selected specifically because it is the only ashwagandha extract with double-blind, placebo-controlled clinical data on cortisol reduction, stress scores, and sleep quality. The evening timing is deliberate — cortisol naturally declines at night, and adaptogenic support during this window maximizes the quality of the skin’s overnight repair environment.
— Dr. Gilbert Maleke, MD · Founder, VitaalSkin
KSM-66®
Most clinically studied ashwagandha extract worldwide
27%
Serum cortisol reduction in KSM-66 clinical trials
22+
Clinical studies backing KSM-66 efficacy
The Stress Dimension of Skin Aging
Cortisol is the most underestimated driver of accelerated skin aging. It suppresses fibroblast collagen synthesis. It degrades the barrier’s tight junction proteins. It maintains the low-grade inflammatory state that makes every visible skin concern worse.
No topical serum reaches this. No retinol corrects it. Stress management has always been part of the clinical picture — it was just missing from the product side.
Step 05 is the protocol’s stress regulation layer — the evening ritual that lowers the biological interference that cortisol creates, so the other four steps can do what they were designed to do.
Not a wellness supplement. A skin longevity strategy.
KSM-66® — The Clinical Standard
The only ashwagandha extract with 22+ double-blind, placebo-controlled clinical studies. Not a proprietary blend — a documented molecule at a documented dose.
Evening Timing Is Deliberate
Cortisol naturally declines at night. Taking KSM-66 before sleep supports that decline — deepening sleep architecture and maximizing the 11pm–4am repair window the skin depends on.
The Keystone of the Inside Protocol
NAD+ restores cellular energy. KSM-66 removes the biological interference that cortisol creates. Together, they address the two primary internal drivers of accelerated skin aging.
What This Blend Supports*
Reduces Cortisol — Skin’s Silent Aggressor*
Clinically demonstrated 27% cortisol reduction with KSM-66 — directly relieving the collagen suppression and barrier degradation that chronic stress causes.
Supports Deep Sleep Architecture*
Improved slow-wave sleep means higher growth hormone secretion and deeper activation of the skin’s peak mitotic window — the 11pm–4am repair phase that no topical can replace.
Quiets Systemic Inflammation*
Adaptogenic stress management supports reduction of the low-grade inflammatory burden that accelerates every form of visible skin aging after 35.
Amplifies Every Topical Active Overnight*
Lower cortisol means the PDRN, HA Cream, and Retinol work in a less inflamed, more biologically receptive environment. Less resistance, more compound result.
Supports Mental Clarity & Cognitive Resilience*
KSM-66 clinical data shows improvements in memory, focus, and cognitive performance under stress — alongside the cortisol reduction that benefits skin.
Complete Adaptogen Stack*
KSM-66 paired with Maca Root, Panax Ginseng, Shatavari, and vitamins D3, B6, B12 — a full-spectrum formula that supports the stress biology from multiple angles simultaneously.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
In use
Video coming soon
Two Capsules.
Before Sleep. Every Evening.
Apply your PM topicals first
Complete your evening ritual: PDRN Serum, then Retinol (3–4 nights/week), then HydraBarrier HA Cream. The topical protocol comes first.
Take 2 capsules with water, before sleep
With 6–8 oz of water. Can be taken with or without food. Evening timing is deliberate — cortisol naturally declines at night, and KSM-66 supports that decline.
Let the overnight system run
While you sleep, the protocol works: KSM-66 supports cortisol decline, NAD+ fuels cellular repair, and the topicals work in a calmer biological environment. Compound results build from here.
Complete the Inside Protocol
Take KSM-66 (PM) alongside NAD+ (AM) for the full inside-out system. NAD+ restores cellular energy. KSM-66 removes cortisol interference. Together, they address the two primary internal drivers of skin aging.
Science, Dosing & Ingredients
Six active ingredients selected for their roles in stress biology, cortisol regulation, and the hormonal architecture that governs how skin ages.
KSM-66® Ashwagandha
600 mg · 5% withanolides
Gold-standard cortisol reduction extract — 22+ clinical studies; ↓27% serum cortisol in double-blind trials; supports sleep architecture and stress resilience
L-Arginine
300 mg
Precursor to nitric oxide; supports healthy blood flow, vascular tone, and cardiovascular wellness
Maca Root + Panax Ginseng
150 mg + 100 mg
Classic adaptogenic stack; supports energy, endurance, and mental performance under stress conditions
Vitamins D3, B6, B12
D3: 20mcg · B6: 2.5mg · B12: 25mcg
Essential micronutrients for energy metabolism, immune regulation, nervous system function, and cognitive health
Evening Protocol
- 1 PDRN Serum (topical, first)
- 2 Retinol + Peptides (3–4×/week)
- 3 HydraBarrier HA Cream (seal)
- 4 KSM-66 (2 capsules, before sleep)
Dosing Guidelines
- 2 capsules per day
- PM Evening, before sleep
- 6oz water minimum
- 30d 60 capsules = 30-day supply
- KSM-66® Ashwagandha600 mg · 5% withanolides standardizedGold-standard cortisol reduction; 22+ clinical studies; ↓27% serum cortisol in double-blind trials
- L-Arginine300 mgNitric oxide precursor; supports healthy blood flow and cardiovascular wellness
- Maca Root Powder150 mg · Lepidium meyenii, rootAdaptogenic root; traditional support for energy and vitality
- Panax Ginseng Powder100 mgClassic adaptogen for mental performance and endurance under stress
- Shatavari Powder50 mg · Asparagus racemosus, rootAyurvedic botanical used in balancing and nourishing formulas
- Vitamins D3, B6, B12D3: 20mcg · B6: 2.5mg · B12: 25mcgEssential micronutrients for energy metabolism, immune function, cognitive health
Do not exceed recommended dose. Pregnant or nursing mothers, children under 18, and individuals with known medical conditions (particularly thyroid conditions) should consult a physician before use. May interact with sedative medications.
Is This Blend Right for You?
Your Questions, Answered
No. KSM-66 is an adaptogen, not a sedative. It supports the natural cortisol decline that enables deep sleep — the effect is calmer, more restorative sleep, not sedation. Most people report waking feeling more rested rather than groggy or slow.
The KSM-66 clinical trials showed measurable cortisol reduction and improved stress scores over 8–12 weeks of daily use. Some people notice improved sleep quality within the first 2–3 weeks. Like all adaptogens, the benefits are cumulative and build with consistency.
Yes, adaptogens can be taken at any time. However, evening timing is the protocol’s recommendation because cortisol naturally declines at night — taking KSM-66 before sleep supports that decline and maximizes the overnight repair window. If morning timing works better for your routine, consistency matters more than timing.
Ashwagandha may affect thyroid hormone levels and can potentially interact with thyroid medications. If you have a thyroid condition or take thyroid medication, consult your physician before use. This applies regardless of the ashwagandha dose.
NAD+ addresses cellular energy depletion — the biological fuel deficit that slows skin repair. KSM-66 addresses cortisol elevation — the inflammatory interference that suppresses it. They are the two primary internal drivers of accelerated skin aging, and they require separate interventions. Together, they form the complete inside layer of the protocol.
We offer a 30-day satisfaction guarantee. If you are not happy with your results, contact us for a full refund — no questions asked.
This Blend Completes the System.
Step 05 — The Keystone.

Step 01
PDRN Serum

Step 02
HydraBarrier Cream

Step 03
Retinol + Peptides

Step 04
NAD+ Capsules

Step 05
KSM-66 Capsules
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