PRO+ RETINOL RENEWAL

$46.00

PRO+ RETINOL RENEWAL

Name: PRO+ RETINOL RENEWAL
Brand: VITAALSKIN
SKU: EVL0REPE
Price: 46.00 USD
Availability: InStock

$46.00

Shipping calculated at checkout.

Physician-Formulated · Dr. Gilbert Maleke, MD

30 mL / 1 fl oz · Made in USA

PM Ritual · Skin Longevity Protocol™ — Step 03

You’ve probably tried retinol before. Maybe it worked until it didn’t — until the peeling, the redness, the feeling that your skin was angry at you.

That was a context problem, not a retinol problem.

With a prepared barrier (Step 01) and a sealing layer ready (Step 02), this is what retinol was always supposed to feel like.

The texture change people actually notice Not a glow you have to explain — a smoothness that's visible in any light. The kind of skin that makes people ask what you’ve been doing differently.
Retinol that doesn’t come at a cost Formulated with Bisabolol and Phospholipids, and dosed at the concentration where results compound without the irritation cycle that makes most people quit.
The night shift, working while you sleep Cellular renewal peaks at night. This serum is applied just 3–4 evenings a week, and those nights quietly add up into visible, structural change over weeks and months.
Progress you can actually keep The ramp-up protocol means your skin builds tolerance gradually — so you never have to restart, never have to take a break, never have to choose between results and comfort.

“Retinol doesn’t fail. Routines fail. The PDRN foundation and the HA Cream seal are what make retinol work the way the clinical literature says it should.”

Physician’s Clinical Rationale

Retinol at 0.1% was selected for one reason: it is the concentration that can be used at 3–4× per week on a prepared barrier and sustained indefinitely. The published literature is unambiguous — collagen mRNA upregulation and MMP inhibition are dose-dependent up to 0.1%, and the marginal gain from higher concentrations is outweighed by the tolerance cost. Most retinol routines fail not because the molecule is wrong, but because the barrier was not prepared (Step 01), the concentration was too high, or there was nothing to seal the active layer (Step 02). This protocol eliminates all three failure modes.

— Dr. Gilbert Maleke, MD · Founder, VitaalSkin

0.1%

Clinical sweet spot — efficacy without tolerance compromise

3–4×

Weekly — where structural results compound sustainably

8wk

To full tolerance — gradual build for lasting results

100% Vegan

30-Day Guarantee

Made in USA

Physician-Formulated

Why It Exists

The Retinol That Stays

Retinol is the most clinically validated ingredient for skin remodeling. The question was never whether it works — it's whether the context is right for it to keep working.

After 35, the challenge isn't finding a retinol that's strong enough. It's finding one you can use consistently, comfortably, for months and years — long enough for biology to genuinely compound.

Step 03 was formulated around that single principle: tolerance by design, so the routine never has to stop.

Not shock therapy. Quiet, compounding renewal.

0.1% — The Sustainable Concentration

Where measurable collagen remodeling occurs at a frequency the skin can maintain. Stronger concentrations offer diminishing returns at a significant tolerance cost.

Comfort Is Built In

Bisabolol calms while retinol works. Phospholipids smooth penetration. The serum was designed to work alongside a prepared barrier — not against it.

Part of a Protocol

Step 03 is where the protocol becomes structural. PDRN prepares the terrain, this serum remodels it, and HydraBarrier seals it — every night it is used.

Key Benefits

What This Serum Does

Accelerates Cell Turnover

New, structurally healthier cells reach the surface faster — visibly refining texture and creating the kind of smoothness that builds over weeks, not days.

Stimulates Collagen Remodeling

Upregulates collagen mRNA expression and inhibits the enzymes that break down existing collagen structure — the closest thing to slowing structural skin aging at the source.

Tolerable by Design

Bisabolol calms as retinol works. Phospholipids smooth penetration. Designed to work alongside the prepared barrier — not against it — so you actually stay with the routine.

Reduces Fine Lines Progressively

Consistent use at 3–4 nights per week produces visible changes in line depth and skin density over 8–12 weeks — the compound effect of biology that doesn’t rush.

Supports a More Even Tone

Accelerated cell turnover reduces surface pigmentation accumulation — skin looks more luminous, more consistent, more like it did before sun exposure and stress started showing.

Compatible With the Full Protocol

Applied after PDRN Serum, before HydraBarrier — the protocol's sealing layer makes retinol more effective and more comfortable in the same evening ritual.

In use Video coming soon

How to Apply

Your Evening Ritual.
3–4 Nights a Week.

1

Apply after PDRN Serum

On retinol evenings, apply the PDRN Serum first. Let it absorb, then apply 3–4 drops of Retinol + Peptides to face and neck.

2

Press gently, avoid the eye contour

Gentle pressing motions — do not rub. Keep 2–3mm away from the eye contour. The serum absorbs quickly into dry skin.

3

Seal with HydraBarrier — always

Apply HydraBarrier HA Cream immediately after. This sealing step is what separates comfortable retinol from irritating retinol. Never skip it.

SPF is non-negotiable the next morning

Retinol increases photosensitivity. Apply SPF 30+ the morning after every application — regardless of season, weather, or time spent outdoors. This is not optional.

A nighttime renewal serum combining retinol with peptides and comfort agents. Every component serves a precise role in making structural skin change both visible and sustainable.

Retinol (0.1%)

Upregulates collagen mRNA expression, inhibits matrix metalloproteinases (collagen-degrading enzymes), accelerates cellular turnover

Hexapeptide-11

Bioactive peptide supporting skin firmness and structural integrity alongside the retinol mechanism

Bisabolol

Anti-inflammatory agent that calms as retinol works — key to maintaining comfort at 3–4× weekly frequency

Phospholipids

Barrier-compatible emollients that smooth penetration and support the skin's lipid matrix during retinol-driven turnover

Aqua (Water), Caprylic/Capric Triglyceride, Phospholipids, Retinol, Aluminum Starch Octenylsuccinate, 1,2-Hexanediol, Butylene Glycol, Propanediol, Hexapeptide-11, Ammonium Acryloyldimethyltaurate/Carboxyethyl Acrylate Crosspolymer, Sodium Polyacrylate, Bisabolol.

Retinol Evening

1 PDRN Serum (always first)
2 Retinol + Peptides Serum
3 HydraBarrier HA Cream (seal)

Non-Retinol Evening & AM

1 PDRN Serum
2 HydraBarrier HA Cream
SPF SPF 30+ (AM, always after retinol nights)

Retinol Ramp-Up Guide — Your 8-Week Path to Full Tolerance

Week 1–22 nights per week — let your barrier adapt
Week 3–43–4 nights per week — building the habit
Week 5+As tolerated, up to nightly — compound results begin here

On non-retinol nights: PDRN Serum + HydraBarrier only — this is the recovery ritual that makes retinol nights more effective.

Golden rule: SPF 30+ the next morning, every time. Retinol increases photosensitivity — skipping SPF undoes the cellular renewal this serum builds.

Retinol (0.1%) — Collagen mRNA upregulation, MMP inhibition, accelerated cell turnover. PM use only.
Hexapeptide-11 — Bioactive peptide supporting structural firmness alongside retinol
Bisabolol — Anti-inflammatory botanical; reduces irritation potential, supports comfort at therapeutic frequencies
Phospholipids — Barrier-compatible emollients; smooth penetration, support lipid matrix integrity
Caprylic/Capric Triglyceride — Lightweight skin-identical emollient base; fast-absorbing texture

Vegan & cruelty-free

Alcohol-free

Fragrance-free

Paraben-free

Mineral oil-free

Phthalate-free

Who It’s For

Is This Serum Right for You?

Women 35+ who want visible, structural skin improvement — refined texture, reduced fine lines, more consistent tone — through a sustainable nightly practice

Anyone who has tried retinol before and stopped — because of irritation, peeling, or sensitivity. The protocol's prepared barrier changes that experience entirely.

Retinol beginners who want to start correctly — at the right concentration, with a proper ramp-up, in a context that makes tolerance possible from the start

All skin types — including sensitive skin, when introduced with the ramp-up protocol and always used with HydraBarrier as the sealing step

Anyone building for the long term — this serum is designed for years of use, not weeks. The results compound. The routine does not have to end.

Frequently Asked

Your Questions, Answered

I've tried retinol before and it made my skin peel and flake. Will this be different?

Almost certainly. The most common reason retinol causes irritation is context — applied to an unprepared barrier, at too high a frequency, without a sealing moisturizer. This protocol eliminates all three problems: Step 01 prepares the barrier, the 0.1% concentration is dosed for sustainable frequency, and HydraBarrier seals the active layer afterward. Start with the ramp-up guide and the experience will be very different.

How quickly will I see results?

Texture refinement can begin within 4–6 weeks of consistent use. Visible collagen and firmness changes take longer — typically 10–12 weeks at 3–4 nights per week. Skin that ages well is built in months and years, not days. The compound effect is real, but it requires patience and consistency.

Is it only for use at night?

Yes, always PM only. Retinol increases photosensitivity and degrades in UV exposure — nighttime use is not optional. You must also apply SPF 30+ the following morning. This is one of the non-negotiable rules of any retinol routine.

Can I use it if I'm pregnant or nursing?

No. Retinol is contraindicated during pregnancy and breastfeeding. Consult your physician before use if you are pregnant, nursing, or planning to become pregnant. This applies to all retinol products regardless of concentration.

Can I combine it with vitamin C or AHA/BHA the same evening?

Not initially. Until you have reached full tolerance (approximately 8 weeks), avoid combining with other actives on retinol evenings. Once tolerance is established, alternating nights with acids is possible — but the protocol's PDRN + Retinol + HydraBarrier combination is already a complete renewal system that doesn't require additional actives.

What is your return policy?

We offer a 30-day satisfaction guarantee. If you are not happy with your results, contact us for a full refund — no questions asked.

Complete Your Protocol