PRO+ RETINOL RENEWAL SERUM
$46.00
Skip to product information
PRO+ RETINOL RENEWAL SERUM
$46.00
Shipping calculated at checkout.
For skin that’s been doing the right things — but hasn’t yet found the retinol it can actually stay with.
Physician-Formulated · Dr. Gilbert Maleke, MD
PM Ritual · Skin Longevity Protocol™ — Step 03
You have probably tried retinol before. Most people quit inside a month, when the flaking shows up long before the glow does.
This one is different. Dosed to be effective, buffered to be kept — because renewal only belongs to the women who don’t give up at week two.
The retinol you’ll actually keep using.
- Wake up looking renewed Smoother texture, softer fine lines, the morning-after look of real repair.
- The retinol you won’t quit Comfort agents calm as it works, so you stay consistent long enough to see it.
- Quiet confidence about the years ahead The peace of doing the one thing with real proof behind it.
“The best retinol is not the strongest one. It is the one you are still using in six months.”
— Dr. Gilbert Maleke, MD · Founder, VitaalSkin
0.1%
The clinically effective, tolerable dose
3-4×
Nights per week, once ready
8 wks
To full nightly tolerance
100% Vegan
30-Day Guarantee
Made in USA
Physician-Formulated
The retinol that stays
You have tried retinol before. Almost everyone has. And most people quit inside a month, when the flaking and the stinging arrive long before any of the good parts do.
Here is what actually went wrong. It was never too weak. It came on too strong, too fast, for a barrier that was not ready for it.
Renewal is not about the strongest formula. It is about the one you can keep using. This serum is dosed and buffered to stay comfortable, night after night, because the results only belong to the women who don't give up.
How it feels
Less about what it does.
More about how you feel doing it.
Renewed each morning
The quiet satisfaction of skin that looks fresher and more awake than it did the day before.
In control of time
The confidence of doing the one proven thing, on purpose, instead of chasing the next trend.
An evening that is yours
The grounding ritual of a proper night routine. A few quiet nights a week that belong to you.
What your skin shows, and when
Honest timelines.
Real biology takes weeks, not hours.
We will never promise 48-hour miracles. Here is what most people notice, in the order they tend to notice it, with consistent use.
Weeks 1–2
Adjustment
Your skin adapts. Used 2 nights a week, a little dryness is normal and settles as your barrier builds tolerance.
Week 4
Smoothness
Texture looks refined and tone more even. Makeup sits better and skin feels smoother to the touch.
Week 8
Renewal
Fine lines look softer. Skin reads fresher, brighter, more awake. This is what people start to notice.
Weeks 12+
Structure
Firmness and density build. This is where retinol's decades of proof compound into lasting change.
These are typical observations, not guarantees. Skin biology varies from person to person. The one variable in your control is consistency.
Proof & formulation
Five actives. Renewal and comfort, together.
A nighttime renewal serum that pairs retinol with peptides and comfort agents. Every component earns its place by making structural change both visible and, just as importantly, sustainable.
Why a physician doses retinol to be kept
In plain terms: retinol speeds your skin's renewal and protects the collagen you already have. Push it too hard and the barrier revolts, and you quit. The real skill is a clinically meaningful dose your skin can tolerate long enough to see results.
That is why it is Step 03. It comes after repair and barrier support, so your skin is ready to renew without the drama.
“The best retinol is not the strongest one. It is the one you are still using in six months.”
Dr. Gilbert Maleke, MD · Founder, VitaalSkin
Retinol (0.1%)
The renewal engine · PM only
Upregulates collagen mRNA, inhibits the enzymes that break collagen down, and accelerates cell turnover. The proven core of the formula.
Hexapeptide-11
The firming peptide
A bioactive peptide supporting firmness and structural integrity alongside the retinol mechanism.
Bisabolol
The comfort keeper
An anti-inflammatory botanical that calms as retinol works. The reason you can stay comfortable at 3 to 4 nights a week.
Phospholipids
The barrier buffer
Barrier-compatible emollients that smooth penetration and support your lipid matrix during retinol-driven turnover.
Caprylic/Capric Triglyceride
The delivery base
A lightweight, skin-identical emollient base for a fast-absorbing, comfortable texture.
Vegan & cruelty-free
Alcohol-free
Fragrance-free
Paraben-free
Mineral oil-free
Phthalate-free
Full ingredient list (INCI)
Aqua (Water), Caprylic/Capric Triglyceride, Phospholipids, Retinol, Aluminum Starch Octenylsuccinate, 1,2-Hexanediol, Butylene Glycol, Propanediol, Hexapeptide-11, Ammonium Acryloyldimethyltaurate/Carboxyethyl Acrylate Crosspolymer, Sodium Polyacrylate, Bisabolol.
How to use it
Your evening ritual. 3 to 4 nights a week.
Retinol is a night active. Start slow, let your barrier build tolerance, and always seal with HydraBarrier. On the nights you skip it, your skin recovers, which is what makes the retinol nights work.
PM · Retinol nights
The renewal night
PDRN first, then this serum on dry skin, sealed with HydraBarrier. 3 to 4 nights a week once your skin is ready.
Recovery nights & AM
The recovery ritual
On off nights and every morning, PDRN and HydraBarrier only. And SPF 30+ each morning, without exception.
Retinol Evening
- PDRN Serum (always first)
- Retinol + Peptides Serum
- HydraBarrier HA Cream (seal)
Non-Retinol Evening & AM
- PDRN Serum
- HydraBarrier HA Cream
- SPF 30+ (AM, always after retinol nights)
RETINOL RAMP-UP GUIDE · YOUR 8-WEEK PATH TO FULL TOLERANCE
Week 1–2
2 nights per week. Let your barrier adapt.
Week 3–4
3 to 4 nights per week. Building the habit.
Week 5+
As tolerated, up to nightly. Compound results begin here.
On non-retinol nights: PDRN Serum and HydraBarrier only. This is the recovery ritual that makes your retinol nights more effective.
Golden rule: SPF 30+ the next morning, every time. Retinol increases photosensitivity, and skipping SPF undoes the cellular renewal this serum builds.
Why VitaalSkin
Most brands sell you products.
We built you a system.
This serum is not a standalone hero. It is Step 03 of one connected method, sequenced to come after repair and barrier support, where every element was chosen for its biological role, never for the marketing.
A system, not a shelf
Five steps designed to work together in sequence. No random layering, no competing formulas.
Inside-out by design
Topical and internal, because skin longevity is a whole-body process, not a surface one.
Vegan and plant-derived
Every active is vegan and of plant origin. Clean formulas, clinically dosed, nothing ornamental.
Formulated by a physician
Built by Dr. Gilbert Maleke on 30 years in preventive medicine, not by a trend team.
Where this began
Prevention, not correction.
For 30 years, Dr. Gilbert Maleke watched patients invest in every part of their health, then treat their skin only after the damage showed. He built VitaalSkin to change the order of things. To support skin before it asks for help, the way the rest of preventive medicine already does.
“Skin does not exist outside the body. It deserves the same preventive thinking we already apply to the rest of our health.”
Dr. Gilbert Maleke, MDPhysician · 30 years in preventive medicine · Founder
Discover the brand →Real results, real words
We do not invent reviews.
Longevity takes time, so we let real results accumulate honestly.
★★★★★
I love how elegant this part of the routine feels. It gives my skin a more refined look without ever feeling too much
Ruth MillerVerified buyer
★★★★★
Step 03 became the part I looked forward to most. My skin feels smoother, looks calmer, and has that healthy glow I want.
Pamela AllenVerified buyer
★★★★
This felt like the step that made everything click. My skin looked more balanced, more polished, and honestly just better cared for.
Chancelle T.Verified buyer
Your questions, answered
Pro+ Retinol Renewal Serum FAQ
Will this retinol make me peel or purge?
Some dryness or light flaking is normal in the first two weeks as your skin adapts. That is why you start at 2 nights a week and build up. The formula is buffered with bisabolol and phospholipids to keep this to a minimum. If you go slowly and always seal with HydraBarrier, most people avoid the harsh peeling stage entirely.
How often should I use it?
Start with 2 nights a week for the first two weeks, move to 3 to 4 nights in weeks 3 to 4, then build up to nightly as tolerated from week 5. On the nights you skip it, use PDRN and HydraBarrier only. That recovery ritual is what makes the retinol nights work.
When will I see results?
Weeks 1 to 2 are adjustment. Smoother texture appears around week 4, softer fine lines and a fresher look by week 8, and firmness and density build from week 12 on. Retinol rewards consistency more than any other active, so the timeline is honest and worth it.
I have failed with retinol before. Will this be different?
Usually, yes. Most people fail retinol because they start too strong, too fast, on an unprepared barrier. This serum is dosed to be effective yet tolerable, buffered with comfort agents, and designed to sit after the repair and barrier steps. That sequence is exactly what makes it something you can keep using.
Do I really need SPF with this?
Yes, without exception. Retinol increases your skin's sensitivity to sunlight, and daytime UV undoes the renewal you build at night. SPF 30+ every morning is non-negotiable while using any retinol.
Can I use it with the PDRN Serum and HydraBarrier?
Yes, that is exactly how it is designed to be used. On retinol nights: PDRN first, then this serum, then HydraBarrier to seal. The repair and barrier steps make retinol far more comfortable and effective.
Is it vegan, and where is it made?
Yes. The formula is vegan and cruelty-free, fragrance-free, and made in the USA in FDA-registered, GMP-certified facilities. See the full INCI list in the formulation section above.
Do I need the whole protocol, or can I start with just this?
You can use this serum on its own. It performs best, and most comfortably, as Step 03 after the PDRN Serum and HydraBarrier, which prepare your skin to tolerate retinol. Many people build up to the full system over time. The complete protocol is available as a bundle when you are ready.
What is your return policy?
Every order is backed by a 30-day guarantee. Give it an honest try for the full window. If it is not right for your skin, contact us and we will make it right.
Where would you like to start?
This serum is just Step 03. The renewal layer.
Start small
Pro+ Retinol Renewal Serum
The renewal step, on its own. Best used after repair and barrier support, so your skin renews without the drama.
Add the serum to cartBest value · save up to 30%
The full 5-step protocol
All five steps, working as one system. Topical and internal, the complete inside-out strategy Dr. Maleke designed. Save 10% one-time, or up to 30% on a monthly subscription.
Explore the protocol →These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Formulated and manufactured in the USA in FDA-registered, GMP-certified facilities.